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ARKA Clinical Decision Support is designed to meet all four criteria for Non-Device CDS under FD&C Act §520(o)(1)(E) and FDA's January 2026 final guidance on Clinical Decision Support Software. Recommendations support, not replace, the clinician's judgment. Every recommendation is anchored in a published guideline or peer-reviewed source, with the basis available for independent review. CLIN emphasizes imaging appropriateness at order entry.
This recommendation is intended to support, not replace, clinical judgment. It is generated by ARKA, software designed to meet the four criteria for Non-Device Clinical Decision Support under FD&C Act §520(o)(1)(E) and FDA's final guidance on Clinical Decision Support Software (January 2026). The clinician is responsible for the final decision.
AIIE Evidence
US first, MRI second for appendicitis in pregnancy — avoid ionizing radiation and gadolinium without forgoing a timely diagnosis.
Pregnant patients with suspected appendicitis are imaged with ultrasound first; when non-diagnostic — common as gestation advances — non-contrast MRI is the next study. CT is reserved for when MRI is unavailable and the diagnosis remains urgent.
The AIIE synthesis above is ARKA-authored; the sources below are the underlying external literature.
Obstetrics & Gynecology · 2017doi:10.1097/AOG.0000000000002355
World Journal of Emergency Surgery · 2020doi:10.1186/s13017-020-00306-3
American College of Radiology · 2024
